کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396438 | 1501187 | 2010 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: Synthesis, characterization, X-ray crystal structures and antitumor comparison Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: Synthesis, characterization, X-ray crystal structures and antitumor comparison](/preview/png/1396438.png)
Transition metal complexes Mn(L1)2 (1), Mn(L2)2 (2), Co(L3)2Cl 4H2O (3), Zn(L3)2 DMF (4), Co(HL4)2(ClO4)2 3H2O (5) and Zn(L5)2 DMF (6) where HL1 = 2-acetylpyridine thiosemicarbazone, HL2 = 2-acetylpyridine N(4)-methylthiosemicarbazone, HL3 = 2-benzoylpyridine thiosemicarbazone, HL4 = 2-benzoylpyridine N(4)-methylthiosemicarbazone and HL5 = 2-benzoylpyridine N(4)-phenylthiosemicarbazone, have been synthesized. The complexes 1, 2, 5 and 6 were characterized by elemental analysis, IR spectra and single-crystal X-ray diffraction studies. Preliminary in vitro screening indicated that all the tested compounds showed significant antitumor activity against K562 leucocythemia cancer cell line.
Preliminary in vitro screening indicated that all the tested compounds showed significant antitumor activity against K562 leucocythemia cell line.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 7, July 2010, Pages 3169–3177