کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
14272 1202 2014 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanotechnology-based intelligent drug design for cancer metastasis treatment
ترجمه فارسی عنوان
طراحی داروهای مبتنی بر فناوری نانو برای درمان متاستاز سرطان
کلمات کلیدی
فناوری نانو، نانومواد سیستم تحویل دارو هدفمند، درمان متاستاز سرطان، پلت فرم نانوذرات
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

Traditional chemotherapy used today at clinics is mainly inherited from the thinking and designs made four decades ago when the Cancer War was declared. The potency of those chemotherapy drugs on in-vitro cancer cells is clearly demonstrated at even nanomolar levels. However, due to their non-specific effects in the body on normal tissues, these drugs cause toxicity, deteriorate patient's life quality, weaken the host immunosurveillance system, and result in an irreversible damage to human's own recovery power. Owing to their unique physical and biological properties, nanotechnology-based chemotherapies seem to have an ability to specifically and safely reach tumor foci with enhanced efficacy and low toxicity. Herein, we comprehensively examine the current nanotechnology-based pharmaceutical platforms and strategies for intelligent design of new nanomedicines based on targeted drug delivery system (TDDS) for cancer metastasis treatment, analyze the pros and cons of nanomedicines versus traditional chemotherapy, and evaluate the importance that nanomaterials can bring in to significantly improve cancer metastasis treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 32, Issue 4, July–August 2014, Pages 761–777
نویسندگان
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