کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1427997 1509158 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dual-modality self-heating and antibacterial polymer-coated nanoparticles for magnetic hyperthermia
ترجمه فارسی عنوان
دوام مونالیزاسیون نانوذرات با پوشش پلیمری با حرارت بالا و ضد باکتری برای هیپرترمی مغناطیسی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


• Synthesized bi-functional self-heating and antibacterial magnetite nanoparticles
• Quantified antibacterial activity of MNPs against biofilms of S. aureus, as well as single cells
• The nanoparticles have high measured SAR and are effective for heat-generation in alternating magnetic fields.

Multifunctional nanoparticles for magnetic hyperthermia which simultaneously display antibacterial properties promise to decrease bacterial infections co-localized with cancers. Current methods synthesize such particles by multi-step procedures, and systematic comparisons of antibacterial properties between coatings, as well as measurements of specific absorption rate (SAR) during magnetic hyperthermia are lacking. Here we report the novel simple method for synthesis of magnetic nanoparticles with shells of oleic acid (OA), polyethyleneimine (PEI) and polyethyleneimine-methyl cellulose (PEI-mC). We compare their antibacterial properties against single gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria as well as biofilms. Magnetite nanoparticles (MNPs) with PEI-methyl cellulose were found to be most effective against both S. aureus and E. coli with concentration for 10% growth inhibition (EC10) of < 150 mg/l. All the particles have high SAR and are effective for heat-generation in alternating magnetic fields.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 63, 1 June 2016, Pages 88–95
نویسندگان
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