کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1428084 1509168 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Local administration of stromal cell-derived factor-1 promotes stem cell recruitment and bone regeneration in a rat periodontal bone defect model
ترجمه فارسی عنوان
تجویز موضعی فاکتور 1 حاصل از سلول های استروما از استخراج سلول های بنیادی و بازسازی استخوان در یک مدل نقص استخوان پریودنتال
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


• We applied collagen membranes loaded with SDF-1 to periodontal bone defects.
• SDF-1 recruited mesenchymal/hematopoietic stem cells to the wound area.
• SDF-1 significantly reduced the CD11b + inflammatory cell response.
• SDF-1 increased vascular formation, induced early bone osteoclastogenesis.
• SDF-1 promoted the quality and quantity of regenerated bone.

Stromal cell-derived factor-1 (SDF-1) recruits adult stem/progenitor cells via its specific receptor, C–X–C motif receptor 4 (CXCR4), to promote heart, kidney and tendon regeneration, but little is known about the effects of SDF-1 on bone regeneration in periodontal diseases. The objective of this study was to investigate whether local administration of SDF-1 in a collagen membrane scaffold enhanced the recruitment of host stem cells and improved periodontal bone defect repair. To this end, bone defects were established on the buccal side of bilateral mandibles in Wistar rats. After application of collagen membranes loaded with SDF-1 or phosphate-buffered saline (PBS) to the defects, the effects of SDF-1 on stem cell recruitment, inflammatory cell responses, angiogenesis, osteoclastogenesis, scaffold degradation, and bone regeneration were evaluated. It showed that SDF-1 recruited host-derived mesenchymal stem cells and hematopoietic stem cells to the wound area and significantly reduced the CD11b + inflammatory cell response. Moreover, SDF-1 increased vascular formation, induced early bone osteoclastogenesis, accelerated scaffold degradation, and promoted the quality and quantity of regenerated bone. Our results suggest that this cell-free approach by local administration of SDF-1 may be an effective strategy for development as a simple and safe technique for periodontal bone regeneration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 53, 1 August 2015, Pages 83–94
نویسندگان
, , , , ,