Green synthesis, characterization of gold and silver nanoparticles and their potential application for cancer therapeutics

• Biosynthesis of gold and silver nanoparticles using plant leaf extract
• The approach is clean, efficient, eco-friendly & economically safe.
• Biosynthesized nanoparticles are biocompatible towards normal and cancer cells.
• Design and development of biosynthesized nanoparticle based drug delivery systems
• Biosynthesized nanoparticles could be useful for cancer and other diseases.

In the present article, we demonstrate the delivery of anti-cancer drug to the cancer cells using biosynthesized gold and silver nanoparticles (b-AuNP & b-AgNP). The nanoparticles synthesized by using Butea monosperma (BM) leaf extract are thoroughly characterized by various analytical techniques. Both b-AuNP and b-AgNP are stable in biological buffers and biocompatible towards normal endothelial cells (HUVEC, ECV-304) as well as cancer cell lines (B16F10, MCF-7, HNGC2 & A549). Administration of nanoparticle based drug delivery systems (DDSs) using doxorubicin (DOX) [b-Au-500-DOX and b-Ag-750-DOX] shows significant inhibition of cancer cell proliferation (B16F10, MCF-7) compared to pristine drug. Therefore, we strongly believe that biosynthesized nanoparticles will be useful for the development of cancer therapy using nanomedicine approach in near future.

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