کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1428290 1509177 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced healing of rabbit segmental radius defects with surface-coated calcium phosphate cement/bone morphogenetic protein-2 scaffolds
ترجمه فارسی عنوان
بهبود زخم ضایعات شعاعی سگ خرگوش با داربست های پروتئین مورفوژنیک استخوانی با پوشش سطح پوشش سیمان کلسیم فسفات
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


• A simple surface-coating method was used to fabricate composite scaffolds.
• Growth factor was protected from rapid depletion via superficial coating.
• Significant promotion of bone regeneration was achieved.
• HPMC-modification displayed optimal effect of bone regeneration.

Large osseous defects remain a difficult clinical problem in orthopedic surgery owing to the limited effective therapeutic options, and bone morphogenetic protein-2 (BMP-2) is useful for its potent osteoinductive properties in bone regeneration. Here we build a strategy to achieve prolonged duration time and help inducting new bone formation by using water-soluble polymers as a protective film. In this study, calcium phosphate cement (CPC) scaffolds were prepared as the matrix and combined with sodium carboxymethyl cellulose (CMC-Na), hydroxypropylmethyl cellulose (HPMC), and polyvinyl alcohol (PVA) respectively to protect from the digestion of rhBMP-2. After being implanted in the mouse thigh muscles, the surface-modified composite scaffolds evidently induced ectopic bone formation. In addition, we further evaluated the in vivo effects of surface-modified scaffolds in a rabbit radius critical defect by radiography, three dimensional micro-computed tomographic (μCT) imaging, synchrotron radiation-based micro-computed tomographic (SRμCT) imaging, histological analysis, and biomechanical measurement. The HPMC-modified CPC scaffold was regarded as the best combination for segmental bone regeneration in rabbit radius.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 44, 1 November 2014, Pages 326–335
نویسندگان
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