Determination of serotonin on platinum electrode modified with carbon nanotubes/polypyrrole/silver nanoparticles nanohybrid

• A new sensor has been developed composed by carbon nanotubes, polypyrrole and silver nanoparticles
• The nanohybrid sensor was applied to the detection of serotonin in plasmatic serum samples
• The analytical application showed no effect of ascorbic acid or uric acid as possible interfering species

A new sensor has been developed by a simple electrodeposition of multi-walled carbon nanotubes (MWCNT), polypyrrole (PPy) and colloidal silver nanoparticles on the platinum (Pt) electrode surface. The Pt/MWCNT/PPy/AgNPs electrode was applied to the detection of serotonin in plasmatic serum samples using differential pulse voltammetry (DPV). The synergistic effect of MWCNT/PPy/AgNPs nanohybrid formed yielded a LOD of 0.15 μmol L− 1 (26.4 μg L− 1). Reproducibility and repeatability values of 2.2% and 1.7%, respectively, were obtained compared to the conventional procedure. The proposed electrode can be an effective material to be used in biological analysis.