Electrospun TiO2 nanofibers decorated Ti substrate for biomedical application

• Processing Ti surface via electrospinning and calcination leads to TiO2 nanofibers.
• The TiO2 electrospun fibers on Ti have diameters between 10 and 100 nm.
• Elaboration with high speed rotating cylinder collector leads to aligned fibers.
• The samples have roughness between 61 and 416 nm and all of them are hydrophilic.
• Cell adherence and viability is more evident on Ti samples with aligned fibers.

Various TiO2 nanofibers on Ti surface have been fabricated via electrospinning and calcination. Due to different elaboration conditions the electrospun fibers have different surface feature morphologies, characterized by scanning electronic microscopy, surface roughness, and contact angle measurements. The results have indicated that the average sample diameters are between 32 and 44 nm, roughness between 61 and 416 nm, and all samples are hydrophilic. As biological evaluation, cell culture with MG63 cell line originally derived from a human osteosarcoma was performed and correlation between nanofibers elaboration, properties and cell response was established. The cell adherence and growth are more evident on Ti samples with more aligned fibers, higher roughness and strong hydrophilic character and such fibers have been elaborated with a high speed rotating cylinder collector, confirming the idea that nanostructure elaboration conditions guide the cells' growth.

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