کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1428545 1509176 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of attapulgite/N-isopropylacrylamide and its use in drug release
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Synthesis of attapulgite/N-isopropylacrylamide and its use in drug release
چکیده انگلیسی


• Attapulgite/N-isopropylacrylamide hydrogels were synthesized and characterized.
• The swelling property of hydrogels was excellent when temperature was below 34.0 °C.
• The composite hydrogels were used for the release of ciprofloxacin lactate.
• The drug release rate increased with the increase of the content of attapulgite.

Environmentally sensitive hydrogels as one of the most potential drug delivery systems have gained considerable interest in recent years. In the present study, we synthesized a newly temperature-responsive composite hydrogel based on attapulgite (ATP) and poly (N-isopropylacrylamide) (PNIPAM) as the localized drug carriers for drug delivery. The as-prepared ATP/PNIPAM hydrogel has large aperture which significantly improved the quantity of adsorption of drugs, exhibiting the excellent properties of drug release. The scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and X-ray diffraction (XRD) were used to characterize the ATP/PNIPAM. The swelling/deswelling behaviors and the release of ciprofloxacin lactate were studied. When the temperature was below the low critical solution temperature (LCST), the swelling property of hydrogels was excellent and the swelling rate was large. And, the drug release rate increased with the increase of the content of attapulgite in the composite hydrogel when it was put in the buffer solution (pH 7.38) at 37.0 °C. Therefore, the composite hydrogels might be very useful for its application in biomedical fields.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 45, 1 December 2014, Pages 170–175
نویسندگان
, , , , , , , , ,