Dermal administration of manganese porphyrin by iontophoresis

• Mn-porphyrin complexes provide promising superoxide dismutase mimics.
• We employed iontophoresis for rapid successful dermal delivery of Mn-porphyrin.
• Mn-porphyrin delivered by iontophoresis penetrated through hairless mouse skin.
• Mn-porphyrin skin penetration increased with iontophoresis time.

The present study describes a technique for dermal administration of cationic manganese porphyrin (Mn-porphyrin), an antioxidant with superoxide dismutase (SOD) activity, in hairless mouse. In general, the stratum corneum on the surface of the skin represents a barrier to passive diffusion of therapeutic agents by standard dermal administration. The present study investigated whether, dermal administration of Mn-porphyrin solution using iontophoresis, the electrical dermal administration technique, could overcome this barrier. We visually confirmed that Mn-porphyrin had penetrated to the reverse side of the hairless mouse skin after iontophoresis for a short period. With prolonged iontophoresis, the ratio of detectable Mn-porphyrin solution on the reverse side of the hairless mouse skin increased.In the future, this technique could provide an innovative approach for delivery of this antioxidant in intractable disease.

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