Application of ionic liquid–TiO2 nanoparticle modified carbon paste electrode for the voltammetric determination of benserazide in biological samples

An ionic liquid–TiO2 nanoparticle modified carbon paste electrode (IL–TiO2/CPE) was used as a fast and sensitive tool for the investigation of the electrochemical oxidation of benserazide using voltammetry. This modified electrode has been fabricated using hydrophilic ionic liquid (n-hexyl-3-methylimidazolium hexafluoro phosphate) as a binder. The modified electrode offers a considerable improvement in voltammetric sensitivity toward benserazide, compared to the bare electrode. Using differential pulse voltammetry (DPV), the electrocatalytic oxidation peak current of benserazide shows a linear calibration curve in the range of 1.0–600 μmol L− 1 benserazide. The limit of detection was equal to 0.4 μmol L− 1. The relative standard deviation (RSD%) for eight successive assays of 10 μmol L− 1 benserazide was 1.1%. Finally, the proposed method was successfully applied to the determination of benserazide in real samples such as blood serum and urine.

In this study, we describe the application of a novel ionic liquid–TiO2 nanoparticle–paste electrode as a suitable voltammetric sensor for the determination of benserazide. The electrocatalytic oxidation peak current of benserazide shows a linear calibration curve in the range of 1.0–600 μmol L− 1 benserazide with a limit of detection equal to 0.4 μmol L− 1.Figure optionsDownload as PowerPoint slideHighlights
► An ionic liquid–TiO2 nanoparticle modified carbon paste electrode was prepared.
► The modified electrode improved the voltammetric sensitivity of benserazide.
► Benserazide could be measured in the range of 1.0–600 μmol L− 1.
► Τhe sensor was applied to the determination of benserazide in real samples.