کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1429008 1509184 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Facile stripping voltammetric determination of haloperidol using a high performance magnetite/carbon nanotube paste electrode in pharmaceutical and biological samples
ترجمه فارسی عنوان
هالوپریدول با استفاده از یک الکترود نانو ذرات مگنتیت / کربن بالا در نمونه های دارویی و بیولوژیکی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


• A sensitive paste using Fe3O4/multi-walled carbon nanotubes was fabricated.
• Haloperidol determination is based on its adsorption on the surface of Fe3O4/MWCNTs.
• Different electrochemical methods and impedance spectroscopy were used for this study.
• Haloperidol was determined in pharmaceutical and biological samples.
• In comparison to other conventional methods, this method is simple, rapid, selective and cost-effective.

Multi-walled carbon nanotubes decorated with Fe3O4 nanoparticles were prepared to construct a novel sensor for the determination of haloperidol (Hp) by voltammetric methods. The morphology and properties of electrode surface were characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy. This modified sensor was used as a selective electrochemical sensor for the determination of trace amounts of Hp. The peak currents of differential pulse and square wave voltammograms of Hp increased linearly with its concentration in the ranges of 1.2 × 10− 3–0.52 and 6.5 × 10− 4–0.52 μmol L− 1, respectively. The detection limits for Hp were 7.02 × 10− 4 and 1.33 × 10− 4 μmol L− 1 for differential pulse and square wave voltammetric methods, respectively. The results show that the combination of multi-walled carbon nanotubes and Fe3O4 nanoparticles causes a dramatic enhancement in the sensitivity of Hp quantification. This sensor was successfully applied to determine Hp in pharmaceutical samples and biological fluids. The fabricated electrode showed excellent reproducibility, repeatability and stability.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 37, 1 April 2014, Pages 264–270
نویسندگان
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