کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1429008 | 1509184 | 2014 | 7 صفحه PDF | دانلود رایگان |
• A sensitive paste using Fe3O4/multi-walled carbon nanotubes was fabricated.
• Haloperidol determination is based on its adsorption on the surface of Fe3O4/MWCNTs.
• Different electrochemical methods and impedance spectroscopy were used for this study.
• Haloperidol was determined in pharmaceutical and biological samples.
• In comparison to other conventional methods, this method is simple, rapid, selective and cost-effective.
Multi-walled carbon nanotubes decorated with Fe3O4 nanoparticles were prepared to construct a novel sensor for the determination of haloperidol (Hp) by voltammetric methods. The morphology and properties of electrode surface were characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy. This modified sensor was used as a selective electrochemical sensor for the determination of trace amounts of Hp. The peak currents of differential pulse and square wave voltammograms of Hp increased linearly with its concentration in the ranges of 1.2 × 10− 3–0.52 and 6.5 × 10− 4–0.52 μmol L− 1, respectively. The detection limits for Hp were 7.02 × 10− 4 and 1.33 × 10− 4 μmol L− 1 for differential pulse and square wave voltammetric methods, respectively. The results show that the combination of multi-walled carbon nanotubes and Fe3O4 nanoparticles causes a dramatic enhancement in the sensitivity of Hp quantification. This sensor was successfully applied to determine Hp in pharmaceutical samples and biological fluids. The fabricated electrode showed excellent reproducibility, repeatability and stability.
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Journal: Materials Science and Engineering: C - Volume 37, 1 April 2014, Pages 264–270