کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1429292 987168 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spectrophotometric and chemometric studies on the simultaneous determination of two benzodiazepines in human plasma
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Spectrophotometric and chemometric studies on the simultaneous determination of two benzodiazepines in human plasma
چکیده انگلیسی

A numerical simple, accurate and precise method based on spectrophotometric data coupled with multivariate calibration methods, PLS and MLR, combined with GA was developed for the simultaneous determination of two benzodiazepines, Clobazam and Flurazepam. A data set of absorption spectra obtained from a calibration set of mixtures containing the compounds was used to build GA-PLS and GA-MLR models. The models were tested using a dataset constructed from the compound synthetic solutions. The better model was also applied to plasma samples. The proposed method requires no preliminary separation steps and can be used for these drugs analysis in quality control laboratories.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 31, Issue 5, 20 July 2011, Pages 992–996
نویسندگان
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