کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1429772 | 987183 | 2011 | 9 صفحه PDF | دانلود رایگان |
Carbohydrate-conjugated gold nanoparticles (GNPs) and gold nanolayers (GNLs), which have recently attracted increasing attention as innovative nano-biomaterials, were successfully synthesized using carbohydrate thiosemicarbazones in an aqueous N-methylmorpholine N-oxide (NMMO) system. This system can dissolve various types of carbohydrates including structural polysaccharides, e.g., cellulose. We observed that oxidative NMMO solvent unexpectedly promoted the immediate reduction of [AuIIICl4]– species to nanosized metallic Au0, that is GNP. One possible mechanism is that the chloride ligand was oxidized to chlorate via the formation of a hypochlorite intermediate. Site-selective S-labeling of sugar reducing ends with thiosemicarbazide may have enabled regulated self-assembly immobilization to the surfaces of GNPs and GNLs. The carbohydrate–gold nanoconjugates possess unique nanoarchitectures and biofunctions for carbohydrate–cell interactions. Novel and simple approaches for the structural design of carbohydrate-decorated GNPs and GNLs in the NMMO system have potential to inspire a new phase in glyco-biomaterials engineering.
Journal: Materials Science and Engineering: C - Volume 31, Issue 6, 12 August 2011, Pages 1221–1229