کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1429814 | 987186 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Microstructure control of TCP/TCP-(t-ZrO2)/t-ZrO2 composites for artificial cortical bone Microstructure control of TCP/TCP-(t-ZrO2)/t-ZrO2 composites for artificial cortical bone](/preview/png/1429814.png)
In this study, bone like continuously porous TCP/TCP-(t-ZrO2)/t-ZrO2 composites with a central channel were fabricated using a multi-pass extrusion process and their mechanical properties and microstructure at different sintering temperatures were investigated. Hydroxyapatite (HAp) powder was used as the raw powder which undergoes a phase transformation into the α-tricalcium phosphate phase (α-TCP) at a sintering temperature of 1500 °C. The external diameter and inside cylindrical hollow core were approximately 10.3 mm and 4.8 mm, respectively. The frame region contained numerous microchannels that extended from one side of the fabricated body to the other. The channeled frame region had a multi-layer microstructure with a TCP/TCP-(t-ZrO2)/t-ZrO2 layer configuration. The inner layer consisted of TCP, which make the wall of the microchannel. The material properties were characterized and microstructural analysis was carried out. The maximum pore size, compressive strength, and relative density of the fabricated system were approximately 86 μm, 53 MPa, and 77% when sintered at 1500 °C. The composites exhibited excellent biocompatibility and cell proliferation behavior resulted in the MTT assay and cell adhesion test using osteoblast-like MG-63 cells.
► In this work we fabricated a composites preform that is a biomimetic structure of bone architecture.
► Unidirectional porous channel with lamellar elcloser, like that of the natural bone was fabricated.
► The HAp-ZrO2 composites system was mechanically strong and showed excellent biocompatibility to be used as an artificial bone.
Journal: Materials Science and Engineering: C - Volume 31, Issue 8, 1 December 2011, Pages 1660–1666