کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1429970 | 987191 | 2010 | 7 صفحه PDF | دانلود رایگان |
Intermolecular forces and morphology demonstrated that there was an excellent compatibility between silk fibroin and gelatin. The silk fibroin/gelatin composite vascular scaffold (inner diameter 4.5 mm) was prepared successfully by electrospinning. The scaffold was treated with ethanol to enhance the water-resistant ability and biomechanical properties. After ethanol treatment, the scaffold could hardly dissolve in the water, and FTIR showed that the conformation of the treated silk fibroin/gelatin composite vascular scaffold was mainly β-sheets. The electrospun silk fibroin/gelatin vascular scaffold possessed outstanding biomechanical properties. In vitro cell culture and in vivo subcutaneous implantation demonstrated that the electrospun silk fibroin/gelatin vascular scaffold had an appropriate biocompatibility. The results indicated that the electrospun silk fibroin/gelatin composite vascular scaffold could be considered as an ideal candidate for tissue-engineered blood vessel.
Journal: Materials Science and Engineering: C - Volume 30, Issue 5, 15 June 2010, Pages 670–676