کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1430006 987192 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fabrication of gelatin–siloxane fibrous mats via sol–gel and electrospinning procedure and its application for bone tissue engineering
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Fabrication of gelatin–siloxane fibrous mats via sol–gel and electrospinning procedure and its application for bone tissue engineering
چکیده انگلیسی

Our strategy is to design and fabricate biomimetic and bioactive scaffolds that resemble the native extracellular matrix as closely as possible so as to create conducive living milieu that will induce cell to function naturally. In the present study, gelatin/siloxane (GS) hybrids were prepared by a sol–gel processing, and electrospinning technique was used to fabricate GS fibrous mats to support the growth of bone marrow-derived mesenchymal stem cells (BMSCs) for tissue engineering of bone. The results indicate that the porous structure and fiber size of the GS fibrous mats can be fine tuned by varying the viscosity of GS precursor solution. Additionally, the Ca2+-containing GS fibrous mats biomimetically deposited apatite in a simulated body fluid (SBF), as well as stimulating its BMSCs proliferation and differentiation in vitro, thereby dignifying its in vitro bioactivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 30, Issue 3, 6 April 2010, Pages 437–444
نویسندگان
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