کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1430294 | 987199 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cationic polysaccharides for gene delivery
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cationic polysaccharides for gene delivery Cationic polysaccharides for gene delivery](/preview/png/1430294.png)
چکیده انگلیسی
Cationic polysaccharides were synthesized by conjugation of various oligoamines including monoquaternary ammonium oligoamines and spermine to oxidized dextran by reductive amination and tested for gene transfection. Monoquaternary ammonium polycations were expected to strongly complex DNA due to increased surface cationic charge of the carrier which may result in a higher transfection yield. However, the transfection yields were much lower compared to the parent vector, dextran–spermine conjugate, which was highly effective both in vitro and in vivo. Modification of dextran–spermine conjugate with increasing amounts of the oleic acid and MPEG resulted in high gene transfection in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 27, Issue 3, April 2007, Pages 595–598
Journal: Materials Science and Engineering: C - Volume 27, Issue 3, April 2007, Pages 595–598
نویسندگان
I. Yudovin-Farber, A.J. Domb,