Magnesium and silver doped CaO–Na2O–SiO2–P2O5 bioceramic nanoparticles as implant materials

Bioceramic nanoparticles of composition xMgO-yAg2O-(40−x)CaO-(20.5−y)Na2O-35.5SiO2-4P2O5 ( x and y values are 0, 2, 4, 6, 8 and 10 mol%) have been prepared in the laboratory by using quick alkali- mediated sol gel method. Role of silver along with magnesium on the the properties of above mentioned bioceramics has been investigated by using X-Ray Diffraction, Transmission Electron Microscopy, Fourier Transform Infrared, Brunauer-Emmett-Teller and Atomic Absorption Spectroscopy techniques. Degradation behavior in Citric Buffer and Simulated Body Fluid has also been investigated. Drug delivery property of prepared samples has been checked with UV-Visible along with Brunauer-Emmett-Teller techniques for antibiotic drug gentamycin. Antimicrobial response against six different microorganisms including Methicillin-Resistant Staphylococcus aureus has been checked. Controlled release of silver ions from our samples to demonstrate their ability to treat infection has been evaluated with the help of heterogeneous model of diffusion controlled mechanism. Cytotoxicity and cell culture (with MG 63 cell lines) studies have also been conducted. It has been observed that samples provide friendly environment for the growth of MG 63 cell lines. Experiments have been conducted to find the suitable chemical composition of implant material with excellent bone regeneration and antimicrobial properties.