کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1476336 991151 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Manufacture of hydroxyapatite beads for medical applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سرامیک و کامپوزیت
پیش نمایش صفحه اول مقاله
Manufacture of hydroxyapatite beads for medical applications
چکیده انگلیسی

Dense, microporous and macroporous hydroxyapatite spherical granules for medical applications were prepared by a new manufacturing procedure. This process is related to a lost wax method and yields beads with a fully controlled porosity, in terms of shape and pore size.A CaCO3 scaffold exhibiting controlled size spherical cavities is impregnated with an aqueous hydroxyapatite suspension. After drying in a plaster mould, a thermal treatment destroys the carbonate scaffold and makes it possible to release the HA beads. By this process, HA beads with diameters in the range of 300 μm to 3 mm are obtained. A post-thermal treatment of the beads allows the ceramic to be densified at various densification levels.Porous ceramics make it possible to functionalise the hydroxyapatite granules by loading the structure with biologically active substances. Drug releasing kinetics in continuous distilled water flow were analysed as a function of time and ceramic porosity. Spheres continue to release the biological molecules for more than 5 days.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the European Ceramic Society - Volume 29, Issue 3, February 2009, Pages 369–375
نویسندگان
, , ,