کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
148594 456419 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Strontium substituted hydroxyapatite porous microspheres: Surfactant-free hydrothermal synthesis, enhanced biological response and sustained drug release
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Strontium substituted hydroxyapatite porous microspheres: Surfactant-free hydrothermal synthesis, enhanced biological response and sustained drug release
چکیده انگلیسی

In the absence of any surfactants, organic solvents or template-directing reagents, the strontium substituted hydroxyapatite (SrHAp) microspheres with hierarchically mesoporous structures and 1.17–5.60 mol.% of Sr substitution were successfully fabricated via hydrothermal method. The morphology observation showed that the fabricated SrHAp porous microspheres in diameters of 50–65 μm were assembled by two-dimensional single-crystal nano-sheets with 30–70 nm in thickness, and up to 3 μm in width and length. The ionic extracts of SrHAp porous microspheres promoted the proliferation, osteogenic differentiation and angiogenic factor expression of human osteoblast-like cells (MG-63), and the microspheres with 3.22 mol.% of Sr substitution showed the best potentially therapeutic applications in bone regeneration field. In addition, the novel 3D architectures of SrHAp resulted in favorable drug loading and sustained release properties. Our study indicated that the fabricated multifunctional SrHAp porous microspheres might be a potential candidate as bioactive bone-regeneration and drug-delivery material.

Figure optionsDownload as PowerPoint slideHighlights
► The mesoporous strontium substituted hydroxyapatite (SrHAp) microspheres were fabricated.
► The ionic extracts of the microspheres promoted the biological responses.
► The architecture of SrHAp resulted in favorable drug-loading and sustained release properties.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Journal - Volume 222, 15 April 2013, Pages 49–59
نویسندگان
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