The selective separation of (S)-amlodipine via a hollow fiber supported liquid membrane: Modeling and experimental verification

A hollow fiber supported liquid membrane (HFSLM) containing the chiral selector O,O′-dibenzoyl-(2S,3S)-tartaric acid ((+)-DBTA) was characterized for the enantioseparation of (R,S)-amlodipine. The influence of various chemical parameters, including the concentration of feed and receiving phases, as well as the carrier concentration in the membrane, were also investigated. Valuable knowledge on the transport mechanisms within this system was thus attained. Furthermore, a mathematical model focusing on the extraction side of the liquid membrane system was presented in order to predict the concentration of (S)-amlodipine at different times. The extraction and recovery of (S)-amlodipine from feed phase were 77.50% and 72.50%, respectively. Extraction equilibrium constant (Kex), distribution ratio (D), permeability (P) and mass transfer coefficients were determined. The aqueous-phase mass-transfer coefficient (kf) and organic-phase mass-transfer coefficient (km) were reported to 2.74 × 10−2 and 2.52 × 10−2 cm/s, respectively. The results showed promising agreement with the experimental data.

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► HFSLM system was established for chiral resolution of racemic amlopidine.
► The extraction and recovery of (S)-amlodipine were 77.50% and 72.50%.
► The enantiomeric flux model was performed and the validity of model was evaluated.
► The mass transfer coefficients (ki) and (km) were 2.74 × 10−2 and 2.52 × 10−2 cm/s.
► Experimental data and theoretical values were found to be in good agreement.