کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
152289 456492 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microfluidic synthesis of amorphous cefuroxime axetil nanoparticles with size-dependent and enhanced dissolution rate
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Microfluidic synthesis of amorphous cefuroxime axetil nanoparticles with size-dependent and enhanced dissolution rate
چکیده انگلیسی

In this work, size-controllable nanoparticles of amorphous cefuroxime axetil (CFA), a poorly water-soluble drug, have been prepared in a Y-junction microchannel reactor (YMCR) by nanoprecipitation for enhancing dissolution rate of CFA. The effects of the operation parameters, such as flow rate of CFA acetone solution, antisolvent flow rate, overall flow rate, CFA concentration and precipitation temperature, on particle size and size distribution were experimentally investigated. The results indicated that the particle size obviously decreased from 1100 to 630 nm with decreasing the CFA solution flow rate from 16 to 2 mL/min, and decreased from 450 to 350 nm with the decreased temperature from 50 to 5 °C. However, with the increase of the antisolvent flow rate at a fixed CFA solution flow rate of 4 mL/min, the particle size obviously decreased from 1229 nm (20 mL/min) to 581 nm (60 mL/min), and then increased to 698 nm (80 mL/min). Also, the particle size firstly decreased and then increased with the increase of the overall flow rate and CFA solution concentration. The as-prepared CFA nanoparticles displayed a size-dependent and significantly enhanced dissolution property when compared to raw CFA and commercial spray-dried CFA. This work suggests that the continuous synthesis in a microfluidic reactor is a simple and economic way to prepare pharmaceutical nanoparticles with tunable sizes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Journal - Volume 162, Issue 2, 15 August 2010, Pages 844–851
نویسندگان
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