کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1538679 | 996618 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A CTRW-based model of time-resolved fluorescence lifetime imaging in a turbid medium
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
مواد الکترونیکی، نوری و مغناطیسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A CTRW-based model of time-resolved fluorescence lifetime imaging in a turbid medium A CTRW-based model of time-resolved fluorescence lifetime imaging in a turbid medium](/preview/png/1538679.png)
چکیده انگلیسی
We develop an analytic model of time-resolved fluorescent imaging of photons migrating through a semi-infinite turbid medium bounded by an infinite plane in the presence of a single stationary point fluorophore embedded in the medium. In contrast to earlier models of fluorescent imaging in which photon motion is assumed to be some form of continuous diffusion process, the present analysis is based on a continuous-time random walk (CTRW) on a simple cubic lattice, the objective being to estimate the position and lifetime of the fluorophore. This can provide information related to local variations in pH and temperature with potential medical significance. Aspects of the theory were tested using time-resolved measurements of the fluorescence from small inclusions inside tissue-like phantoms. The experimental results were found to be in good agreement with theoretical predictions provided that the fluorophore was not located too close to the planar boundary, a common problem in many diffusive systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Optics Communications - Volume 283, Issue 23, 1 December 2010, Pages 4832-4839
Journal: Optics Communications - Volume 283, Issue 23, 1 December 2010, Pages 4832-4839
نویسندگان
Victor Chernomordik, Amir H. Gandjbakhche, Moinuddin Hassan, Sinisa Pajevic, George H. Weiss,