کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1548137 997722 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Facile immobilization of heparin on bioabsorbable iron via mussel adhesive protein (MAPs)
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد مواد الکترونیکی، نوری و مغناطیسی
پیش نمایش صفحه اول مقاله
Facile immobilization of heparin on bioabsorbable iron via mussel adhesive protein (MAPs)
چکیده انگلیسی
Motivated by adhesive proteins in mussels, strategies using dopamine to modified surface have become particularly attractive. In the present work, we developed a novel and convenient method to modify the biodegradable Fe plates with heparin. Iron was first treated by a facile one-step pH-induced polymerization of dopamine, and then a high density heparin was successfully grafted onto the surface via coupling with polydopamine (PDA) active layer. Heparin immobilization contributed much longer blood clotting coagulation time than the pure Fe sample, and hence reduced the risk of thrombosis. Cell viability tests suggested that the heparin modified Fe plates were more favorable to the proliferation of ECV304 cells. In summary, the heparin modified Fe plates with good anti-thrombus properties and inhibiting the proliferation of VSMC cells provide great prospects for biodegradable iron.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Natural Science: Materials International - Volume 24, Issue 5, October 2014, Pages 458-465
نویسندگان
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