کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1588804 1515138 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original and regenerating lizard tail cartilage contain putative resident stem/progenitor cells
ترجمه فارسی عنوان
غضروف دمدمی مزاج اصلی و بازسازی شده حاوی سلول های قاعدگی / پرونوتیک ساکنان قابل پیش بینی است
کلمات کلیدی
مارمولک، مهره های دم بازسازی غضروف، اتادادیوگرافی، ایمونوهیستوشیمی،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد دانش مواد (عمومی)
چکیده انگلیسی
Regeneration of cartilaginous tissues is limited in mammals but it occurs with variable extension in lizards (reptiles), including in their vertebrae. The ability of lizard vertebrae to regenerate cartilaginous tissue that is later replaced with bone has been analyzed using tritiated thymidine autoradiography and 5BrdU immunocytochemistry after single pulse or prolonged-pulse and chase experiments. The massive cartilage regeneration that can restore broad vertebral regions and gives rise to a long cartilaginous tube in the regenerating tail, depends from the permanence of some chondrogenic cells within adult vertebrae. Few cells that retain tritiated thymidine or 5-bromodeoxy-uridine for over 35 days are mainly localized in the inter-vertebral cartilage and in sparse chondrogenic regions of the neural arch of the vertebrae, suggesting that they are putative resident stem/progenitor cells. The study supports previous hypothesis indicating that the massive regeneration of the cartilaginous tissue in damaged vertebrae and in the regenerating tail of lizards derive from resident stem cells mainly present in the cartilaginous areas of the vertebrae including in the perichondrium that are retained in adult lizards as growing centers for most of their lifetime.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Micron - Volume 78, November 2015, Pages 10-18
نویسندگان
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