کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1589121 | 1515167 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Automated labelling of cancer textures in colorectal histopathology slides using quasi-supervised learning Automated labelling of cancer textures in colorectal histopathology slides using quasi-supervised learning](/preview/png/1589121.png)
Quasi-supervised learning is a statistical learning algorithm that contrasts two datasets by computing estimate for the posterior probability of each sample in either dataset. This method has not been applied to histopathological images before. The purpose of this study is to evaluate the performance of the method to identify colorectal tissues with or without adenocarcinoma. Light microscopic digital images from histopathological sections were obtained from 30 colorectal radical surgery materials including adenocarcinoma and non-neoplastic regions. The texture features were extracted by using local histograms and co-occurrence matrices. The quasi-supervised learning algorithm operates on two datasets, one containing samples of normal tissues labelled only indirectly, and the other containing an unlabeled collection of samples of both normal and cancer tissues. As such, the algorithm eliminates the need for manually labelled samples of normal and cancer tissues for conventional supervised learning and significantly reduces the expert intervention. Several texture feature vector datasets corresponding to different extraction parameters were tested within the proposed framework. The Independent Component Analysis dimensionality reduction approach was also identified as the one improving the labelling performance evaluated in this series. In this series, the proposed method was applied to the dataset of 22,080 vectors with reduced dimensionality 119 from 132. Regions containing cancer tissue could be identified accurately having false and true positive rates up to 19% and 88% respectively without using manually labelled ground-truth datasets in a quasi-supervised strategy. The resulting labelling performances were compared to that of a conventional powerful supervised classifier using manually labelled ground-truth data. The supervised classifier results were calculated as 3.5% and 95% for the same case. The results in this series in comparison with the benchmark classifier, suggest that quasi-supervised image texture labelling may be a useful method in the analysis and classification of pathological slides but further study is required to improve the results.
Figure optionsDownload high-quality image (390 K)Download as PowerPoint slideHighlights
► We present a framework for quasi-supervised histopathology image texture labelling.
► The strategy eliminates the need for manual labelling of normal and cancer tissues.
► The learning algorithm contrasts a mixed texture group to cancer-free textures.
► The proposed scheme is robust to texture feature alternatives.
► The labelling performance was close to a classifier trained on ground truth data.
Journal: Micron - Volume 47, April 2013, Pages 33–42