کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1589287 1001984 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stages in tropoelastin coalescence during synthetic elastin hydrogel formation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد دانش مواد (عمومی)
پیش نمایش صفحه اول مقاله
Stages in tropoelastin coalescence during synthetic elastin hydrogel formation
چکیده انگلیسی

Synthetic human tropoelastin was chemically cross-linked to form elastic hydrogel-like structures in vitro. Discrete stages were identified during elastic hydrogel formation by cross-linking tropoelastin with bis(sulfosuccinimidyl) suberate at a range of protein concentrations during this process. In the early stages of this process, particles with the same dimensions as tropoelastin were seen. As hydrogel formation progressed, monomer width fibres were also observed. Overall, four distinct stages were identified: (1) tropoelastin monomers form discrete particles in the order of 200 nm diameter, (2) these particles merge to form larger spheres, (3) spheres coalesce into open linked networks, (4) coalesced spheres consolidate to form a porous structure to give synthetic elastin hydrogels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Micron - Volume 41, Issue 3, April 2010, Pages 268–272
نویسندگان
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