Quantitative statistical analysis, optimization and noise reduction of atomic resolved electron energy loss spectrum images

► We have statistically analyzed atomic resolution electron energy loss spectrum images. ► We quantitatively determine the effects of principal component analysis (PCA). ► PCA has marginal affect on signal-to-noise ratio (SNR). ► PCA has significant affect on standard deviation of SNR. ► Experimental-theoretical comparison highlights complex nature of electron scattering.