Preparation of hydroxyapatite nanoparticles facilitated by the presence of β-cyclodextrin

Hydroxyapatite nanoparticles with uniform morphology have been successfully synthesized by a chemical coprecipitation method and facilitated by the presence of the β-cyclodextrin. X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM); and Fourier Transformed Infrared Spectroscopy (FT-IR) were used in order to characterize the hydroxyapatite samples. The experimental results indicate that the obtained HA is in the range of 20–50 nm. Also it was found that the content of β-CD has an impact on the purity of the HA as well in the particle size of the hydroxyapatite nanoparticles.

► It was found that β-cyclodextrin can control the particle size in the production of nanohydroxyapatite.
► Particle size in the range of 30–50 nm was obtained.
► A new simple methodology for the preparation of hydroxyapatite nanoparticles with a well controlled size and narrow particles size distribution was developed.