A novel in situ deposition of hydroxyapatite nanoplates using anodization/hydrothermal process onto magnesium alloy surface towards third generation biomaterials

• Anodization/HT process was performed on the AZ31B Mg alloy.
• HA nanoplates like shape structure was generated after HT process.
• An improved bioactivity and corrosion resistance of the alloy was resulted.
• The generated nanoplates was found to mimic that in natural bone.

Third-generation biomaterials aim to stimulate specific cellular responses at the molecular level, these materials characterized with a resorbable and bioactivity that help body heal once they have been implanted. Here, a biomimetic method was used to generate hydroxyapatite (HA) nanoplates on the surface of AZ31B Mg alloy via anodization in simulated body fluid (SBF), followed by a hydrothermal (HT) process. The resulting nanoplates were characterized using FE-SEM, XRD, and FT-IR, surface hydrophobicity, in addition, corrosion was assessed electrochemically. The excellent bioactivity of the treated samples compared with naked ones were confirmed in vitro with MC3T3-E1 osteoblastic cells with significant growth and proliferation.

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