The combination of meltblown and electrospinning for bone tissue engineering

• Introducing of novel fibrous three-component scaffold production technology.
• Introducing production of meltblown nonwoven from biodegradable polymer.
• Structural analysis of micro/nano fibrous ratio in the scaffolds.
• Micro-nano fibrous/particles materials and its combinations in-vitro testing.

Materials combining meltblown and electrospinning products with hydroxyapatite powder as potential scaffolds for bone tissue engineering are presented here. The combination of these technologies and parameters and final micro-nanofibrous products are introduced too. The in-vitro testing compared meltblown material, meltblown material with sputtered particles, meltblown material combined with electrospun fibers, meltblown material combined with electrospun fibers and sputtered particles. All the fibrous materials are produced from polycaprolactone. The first in-vitro tests showed the high potential of developed composite materials in bone tissue engineering. The structure of the tested materials allows osteoblasts to proliferate into the sample inner structure with the significant contribution of nanofiber content to cell proliferation.

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