Porous Ca–Si-based nanospheres: A potential intra-canal disinfectant-carrier for infected canal treatment

The aim of this study is to develop a new intra-canal disinfectant-carrier for infected canal treatment. To achieve this purpose, a new porous Ca–Si (CS)-based nanosphere was synthesized and characterized. Results showed that the nanospheres can infiltrate into dentinal tubules and released the ampicillin over one week time in a sustained manner. The release of ampicillin from spheres has significant antibacterial property. Extensive and well-organized in vitro mineralization and crystallization of apatite were induced on the surface of dentin slices covered by CS nanospheres. All these features indicate that the porous CS nanospheres may be developed into a new intra-canal disinfectant-carrier for infected canal treatment.

► We synthesized a novel porous Ca–Si (CS) nanosphere.
► CS nanospheres can be infiltrated into dentinal tubules.
► CS nanospheres possess excellent in vitro mineralization.
► CS nanospheres possess the ability for releasing antibiotics and kill bacteria.
► CS nanospheres are a new intra-canal disinfectant for infected canal treatment.