کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1695140 | 1519099 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Drug release from layered double hydroxides and from their polylactic acid (PLA) nanocomposites Drug release from layered double hydroxides and from their polylactic acid (PLA) nanocomposites](/preview/png/1695140.png)
Layered double hydroxides (LDH) with intercalated diclofenac, chloramphenicol and ketoprofen have been supported and dispersed in semicrystalline polylactic acid (PLA). The solids have been characterized by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA) and Fourier-Transform infrared spectroscopy (FT-IR). Drug release from the systems prepared was followed by UV–vis spectroscopy. Release is almost complete after 24 h for ketoprofen from the drug-LDH systems, but lower values were measured for the other drugs (60 and 80%, respectively, for diclofenac and chloramphenicol); however, when supported on PLA the release was much slower and could be related to the degradation of the polymer.
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► Drug release from layered double hydroxides (LDHs) is studied.
► Release from LDH-drug nanocomposites with polylactic acid is studied.
► Almost total release from the LDHs is reached after 24 h.
► Release from the nanocomposites is not complete even after 3 months.
Journal: Applied Clay Science - Volume 71, January 2013, Pages 1–7