Characterisation of Diclofenac, Ketoprofen or Chloramphenicol Succinate encapsulated in layered double hydroxides with the hydrotalcite-type structure

Three series of hybrid organic–inorganic layered double hydroxide samples containing Zn2 + and/or Mg2 + and Al3 + in the brucite-like layers (nominal M2 +/Al molar ratio 2:1) and Diclofenac, Ketoprofen or Chloramphenicol Succinate as counter-anions, were synthesized by coprecipitation using drug/Al molar ratios of 2:1 to prepare the starting solutions. All samples have been characterised by element chemical analysis, powder X-ray diffraction, FT-IR spectroscopy, thermal analysis and morphology analysis (Scanning Electron Microscopy). The nanohybrids here prepared show a rather high crystallinity degree and the drug molecules are strongly interacting with the brucite-like layers.

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► Chloramphenicol, Diclofenac and Ketoprofen are intercalated in Zn, Al aluminium LDHs.
► The orientations of the molecules in the interlayer have been determined.
► The intercalated drugs decompose at higher temperatures than in isolated form.
► Strong interactions develop between the layer and the drug molecules.