کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1695652 | 1011869 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Biopolymer–clay hydrogel composites as drug carrier: Host–guest intercalation and in vitro release study of lidocaine hydrochloride Biopolymer–clay hydrogel composites as drug carrier: Host–guest intercalation and in vitro release study of lidocaine hydrochloride](/preview/png/1695652.png)
The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.
Research highlights
► Intercalation of Lidocaine in the interlayer of montmorillonite by ion exchange.
► Blending of hybrid with alginate to retard the release in gastric environments.
► In vitro Lidocaine release from hydrogel composites.
Journal: Applied Clay Science - Volume 52, Issue 4, June 2011, Pages 364–367