Optimization study on accelerator driven system design for effective transmutation of Iodine-129

► Transmutation of Iodine-129 in an accelerator driven system (ADS) was studied. ► Sodium iodide assembly loadings inside the core of ADS and in the surrounding core region were considered. ► The introduced concept of ADS is able to transmute simultaneously minor actinides and Iodine-129 with support of 10 PWRs.