کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1793027 | 1023663 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
On-line concentration measurement for anti-solvent crystallization of β-artemether using UV-vis fiber spectroscopy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Concentration monitoring is essential for quality control of crystallizations. This work establishes the technical feasibility of Ultraviolet (UV) fiber spectroscopy for on-line concentration measurement of anti-solvent crystallization of β-artemether, where ethanol was selected as solvent and water was used as anti-solvent. The orthogonal signal correction (OSC) algorithm was selected to preprocess the UV spectra, and the results showed that the wavelength shift of UV maximum absorbance of β-artemether in ethanol+water solvent mixtures can be effectively eliminated by OSC algorithm. Then models for prediction of β-artemether concentration based on Lambert-Beer law were developed, and the models were verified by comparison between the training set and the validation set, as well as its directly application to the anti-solvent crystallization process of β-artemether. The results show that the model is suitable for on-line concentration measurement of anti-solvent crystallization of β-artemether, with reasonable accuracy and precision.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crystal Growth - Volume 314, Issue 1, 1 January 2011, Pages 185-189
Journal: Journal of Crystal Growth - Volume 314, Issue 1, 1 January 2011, Pages 185-189
نویسندگان
Yang Zhang, Yanbin Jiang, Duanke Zhang, Kaixia Li, Yu Qian,