Solubility and dissolution kinetics of calcium oxalate renal calculi in solutions containing l-arginine: In-vitro experiments

The kinetics of dissolution of calcium oxalate (CaOX) calculi in physiological solutions containing l-arginine at different concentrations were studied using the change in the Archimedean weight of samples immersed in the solution. It was faound that arginine, which is a normal constituent of human urine, acts at increased concentrations as a dissolving agent with respect to CaOX calculi. The possible effect of l-arginine as a natural regulator of CaOX supersaturation and crystalization in human urine is also disscused.