کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
17942 | 42706 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel strategy of enhanced glutathione production in high cell density cultivation of Candida utilis—Cysteine addition combined with dissolved oxygen controlling
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Effects of dissolved oxygen (DO) concentration on glutathione (GSH) production and cysteine oxidation were investigated in high cell density cultivation of Candida utilis. Lower DO concentration favors cysteine absorption but retards GSH production. Higher DO promotes GSH production but accelerates cysteine oxidation in the broth. A two-step DO control strategy was developed and compared for the potential in enhancing GSH production and cysteine absorption. By using the two-step DO control strategy, a 40% decrease in cysteine addition and a 13% increase in GSH production are observed as compared with that at constant DO of 40%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Enzyme and Microbial Technology - Volume 42, Issue 3, 4 February 2008, Pages 284–289
Journal: Enzyme and Microbial Technology - Volume 42, Issue 3, 4 February 2008, Pages 284–289
نویسندگان
Guo-Bin Liang, Guo-Cheng Du, Jian Chen,