Soldering DNA to graphene via 0, 1 and 2-point contacts: Electrochemical impedance spectroscopic investigation

DNA is one of the most programmable molecules available till date and it is immensely important for nanoarchitectonic works. Herein, we investigate the influence of topological constraints of single stranded DNA, which is attached to a graphene sheet, on its ability to hybridize with a complementary strand. These findings are expected to have a profound impact on nanoarchitectonic, bioelectronic and biosensing applications of graphene.

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► ssDNA is attached to graphene sheet via hydroxysulfosuccinimide chemistry.
► The attachment is done at both ends of ssDNA strand, at one end with one loose end and without attachment.
► Hybridization on 1-soldering point attached ssDNA is much more efficient than on 2-soldering points attached ssDNA.