کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
18256 | 42715 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transformation of steroids by Trichoderma hamatum
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Trichoderma hamatum KCh25 was used to study the mode of transformation of a series of 3-oxosteroids. This potential has not been previously examined. The strain promoted 1-dehydrogenation, which have been rarely observed in fungi cultures. The metabolism of cortexolone resulted in efficient conversion to 1-dehydrocortexolone, with no other product isolated. The other routes of biotransformations of the substrates included: hydroxylation at equatorial 11α, 6α, and 12β positions, ester bond hydrolysis, oxidation of 17α-hydroxyl group, C-17/C-20 bond scission, and the ring D-lactonization. The correlation between a steroid compound structure and the transformation profile and also succession of the observed reactions has been noticed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Enzyme and Microbial Technology - Volume 40, Issue 6, 2 May 2007, Pages 1615–1621
Journal: Enzyme and Microbial Technology - Volume 40, Issue 6, 2 May 2007, Pages 1615–1621
نویسندگان
Agnieszka Bartmańska, Jadwiga Dmochowska-Gładysz,