کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1875696 | 1532090 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of 68Ga-labelled DOTA-peptides using a manual labelling approach for small-animal PET imaging
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
68Ga-DOTA-peptides are a promising PET radiotracers used in the detection of different tumours types due to their ability for binding specifically receptors overexpressed in these. Furthermore, 68Ga can be produced by a 68Ge/68Ga generator on site which is a very good alternative to cyclotron-based PET isotopes. Here, we describe a manual labelling approach for the synthesis of 68Ga-labelled DOTA-peptides based on concentration and purification of the commercial 68Ga/68Ga generator eluate using an anion exchange-cartridge. 68Ga-DOTA-TATE was used to image a pheochromocytoma xenograft mouse model by a microPET/CT scanner. The method described provides satisfactory results, allowing the subsequent 68Ga use to label DOTA-peptides. The simplicity of the method along with its implementation reduced cost, makes it useful in preclinical PET studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 107, January 2016, Pages 113-120
Journal: Applied Radiation and Isotopes - Volume 107, January 2016, Pages 113-120
نویسندگان
Eduardo Romero, Alfonso MartÃnez, Marta Oteo, Angel GarcÃa, Miguel Angel Morcillo,