کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1875864 | 1532109 | 2014 | 5 صفحه PDF | دانلود رایگان |
• BNCT with the use of l-BPA was applied for three human clear cell sarcoma (CCS) cell lines.
• BNCT trial was performed on a newly established intramuscularly CCS-bearing animal model.
• A significant decrease of the tumor-volume was seen by single BNCT with the use of l-BPA.
• A multiple BNCT application would be required for controlling the growth of any residual tumors.
Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In our previous study, the tumor disappeared under boron neutron capture therapy (BNCT) on subcutaneously-transplanted CCS-bearing animals. In the present study, the tumor disappeared under this therapy on model mice intramuscularly implanted with three different human CCS cells. BNCT led to the suppression of tumor-growth in each of the different model mice, suggesting its potentiality as an alternative to, or integrative option for, the treatment of CCS.
Journal: Applied Radiation and Isotopes - Volume 88, June 2014, Pages 59–63