10B-NMR determination of 10B-BPA, 10B-BPA–fructose complex and total 10B in blood for BNCT

• First 10B-NMR determination of 10B-BPA and 10B-BPA–fructose complex in blood.
• Total 10B concentration in blood could be obtained by this method
• The detection limit was 3 ppm for total 10B

First spontaneous, noninvasive determination method of 10B-BPA, 10B-BPA–fructose complex, and total 10B in blood is described. 10B-NMR measurement with 100,000 FT accumulation enables us to obtain the result within 100 min/sample. The detection limits for the simultaneous analysis were 3 ppm, 3 ppm and 6 ppm for 10B-BPA, 10B-BPA–fructose complex and total 10B respectively in this study. By this method, we can actually discuss behavior of the 10B-BPA–fructose complex in blood.