کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1875872 | 1532109 | 2014 | 5 صفحه PDF | دانلود رایگان |
• We performed experimental boron biodistribution studies for lung metastases.
• 3 protocols employing BPA and GB-10 would be therapeutically useful.
• BNCT at RA-3 would be potentially therapeutic for experimental lung metastases.
BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76 ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.
Journal: Applied Radiation and Isotopes - Volume 88, June 2014, Pages 94–98