Labelling of commercially available human serum albumin kits with 68Ga as surrogates for 99mTc-MAA microspheres

An alternative method of labelling different commercially available human serum albumin kits with generator produced 68Ga as possible surrogate markers for the investigation of the biodistribution, and to exclude a possible lung shunt in patients with solid primary tumours and liver metastases by positron emission-tomography (PET) and effective substitute for 99mTc HSA as a PET perfusion tracer is described. The radioactive labelling with 68Ga was based on the elution of a commercial 68Ge/68Ga generator system, which uses a modified tin dioxide column to absorb 68Ga. We obtained 68Ga-MAA and 68Ga-HSA in radiochemical yields of 79±5% with less than 5% free 68Ga. The whole procedure takes a total of less than 30 min from elution to the final product.