کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1877272 1042061 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation of 99mTc-nitrido asymmetrical heterocomplex with 4-(cyclohexylpiperazin-1-yl)-dithioformate and its biological evaluation as a potential myocardial imaging agent
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Preparation of 99mTc-nitrido asymmetrical heterocomplex with 4-(cyclohexylpiperazin-1-yl)-dithioformate and its biological evaluation as a potential myocardial imaging agent
چکیده انگلیسی

Potassium 4-(cyclohexylpiperazin-1-yl)-dithioformate (HPDTF) was synthesized from 1-cyclohexylpiperazine. The corresponding 99mTc-nitrido asymmetrical heterocomplex [99mTcN(PNP5)(HPDTF)]+ [PNP5=bis-(dimethoxypropylphosphinoethyl)ethoxyethylamine] was prepared via the [99mTcN]int2+ precursor in high yields (>95%) and characterized by HPLC and paper electrophoresis. It was found to be lipophilic and cationic, with high stability in vitro. Studies of its biodistribution in mice showed high heart uptake and good myocardial retention ((11.12±1.41)% ID/g at 5 min and (10.88±1.45)% ID/g at 120 min), as well as rapid clearance from liver, blood and soft tissues. At 60 min post-injection, the heart-to-liver, heart-to-lung and heart-to-blood ratios were 1.30, 3.89 and 27.56, respectively, which suggested that the complex might be suitable for myocardial imaging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 65, Issue 10, October 2007, Pages 1134–1139
نویسندگان
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