Optimizing the transfer of [18F]fluoride from aqueous to organic solvents by electrodeposition using carbon electrodes

The effect of varying structural modifications of carbon anodes, ranging from thin layers of crystalline boron-doped diamond up to highly graphitic bulk materials, was systematically examined for the possibility of electrochemical fixation and desorption of no-carrier-added [18F]fluoride from an aqueous solution. Pyrolysed carbon, i.e. “glassy carbon” (Sigradur®G), proved as the most efficient material for deposition and release. An overall radiochemical yield of about 60% was achieved when using this for fixation and DMSO/ionic additive as organic solution for the release of [18F]fluoride.