کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1877669 | 1532125 | 2012 | 6 صفحه PDF | دانلود رایگان |
The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [18F]FPCIT (a dopamine transporter imaging radioligand) and [18F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [18F]FPCIT was significantly reduced and that of [18F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.
► The dopaminergic integrity in unilateral 6-OHDA was evaluated by dual PET tracers.
► The brain uptake and BPND of [18F]FPCIT was greatly decreased.
► The brain uptake and BPND [18F]fallypride was slightly increased.
► DAT are down-regulated and D2R are up-regulated.
Journal: Applied Radiation and Isotopes - Volume 70, Issue 12, December 2012, Pages 2689–2694